Nūhou

Ke alo nei i ka hoʻololi mau ʻana o COVID-19, ʻaʻole maikaʻi ka hana kuʻuna o ka hoʻopili ʻana.
Ua ʻike ʻo Polofesa Huang Bo a me Qin Chuan hui o CAMS (Chinese Academy of Medical Sciences) he mau hoʻolālā maikaʻi nā alveolar macrophages i hoʻopaʻa ʻia no ka hoʻopaʻa mua ʻana i ka maʻi COVID-19, a loaʻa i ʻelua mau lāʻau lapaʻau maʻamau i ka hoʻohālike ʻiole COVID-19.Ua paʻi ʻia nā hopena noiʻi pili ma ka pūnaewele ma ka puke pai honua, ka hoʻololi ʻana i ka hōʻailona a me ka lāʻau lapaʻau.
"ʻAʻole kēia haʻawina e hāʻawi wale i kahi mālama palekana a maikaʻi hoʻi no COVID-19, akā he hoʻāʻo wiwo ʻole hoʻi e 'hoʻohana i nā lāʻau kahiko no ka hoʻohana hou', e hāʻawi ana i kahi ala hou o ka noʻonoʻo e koho i nā lāʻau lapaʻau no COVID-19."Ua koʻikoʻi ʻo Huang Bo i ka hālāwai ninaninau me ka mea hoʻopuka o ka ʻepekema a me ka ʻenehana i kēlā me kēia lā Ma ʻApelila 7th.
E like me ka baluna, ʻo ka alveoli ka ʻāpana kumu o ka māmā.ʻO ka ʻili o loko o ka alveoli i kapa ʻia ʻo ka pulmonary surfactant layer, kahi i haku ʻia me kahi ʻāpana lahilahi o ka momona a me ka protein e mālama ai i ka alveoli i kahi kūlana lōʻihi.I ka manawa like, hiki i kēia membrane lipid ke hoʻokaʻawale i waho mai loko o ke kino.ʻAʻole hiki i nā molekole lāʻau lapaʻau koko, me nā antibodies, ke hele i loko o ka papa hana alveolar surface.
ʻOiai ua hoʻokaʻawale ka papa surfactant alveolar i waho mai loko mai o ke kino, aia i kā mākou ʻōnaehana pale i kahi papa o nā phagocytes kūikawā, i kapa ʻia ʻo macrophages.Ke komo nei kēia mau macrophages i ka papa surfactant alveolar a hiki ke phagocytize i nā ʻāpana a me nā microorganism i loko o ka ea inhaled, i mea e mālama ai i ka maʻemaʻe o ka alveoli.
"No laila, i ka manawa i komo ai ʻo COVID-19 i ka alveoli, nā macrophages alveolar e hoʻopili i nā ʻāpana maʻi ma ko lākou membrane cell surface a moni iā ​​lākou i loko o ka cytoplasm, kahi e hoʻopili ai i nā vesicle o ka maʻi, i kapa ʻia nā endosomes."Ua ʻōlelo ʻo Huang Bo, "hiki i nā endosomes ke hāʻawi i nā ʻāpana virus i nā lysosomes, kahi hale hoʻolei ʻōpala i loko o ka cytoplasm, i mea e hoʻoheheʻe ai i ka maʻi i loko o nā waikawa amino a me nā nucleotides no ka hoʻohana hou ʻana i nā cell."
Eia nō naʻe, hiki i ka COVID-19 ke hoʻohana i ke kūlana kikoʻī o nā macrophages alveolar e pakele ai mai nā endosomes, a ma ka huli ʻana e hoʻohana i nā macrophages i ka hoʻopili ʻana iā ia iho.
"Ma ke kino, hoʻohana ʻia nā bisphosphonates e like me alendronate (AlN) i ka mālama ʻana i ka osteoporosis ma o ka huli ʻana i nā macrophages;ʻO ka lāʻau glucocorticoid e like me dexamethasone (DEX) he lāʻau anti-inflammatory maʻamau.Ua ʻōlelo ʻo Huang Bo ua ʻike mākou ua hiki iā DEX a me AlN ke hoʻopaʻa ʻia i ka pakele o ka maʻi mai nā endocytosomes ma o ka huli ʻana i ka hōʻike o CTSL a me ka waiwai pH o nā endosomes.
Ma muli o ka paʻakikī o ka hoʻokele ʻana o ka ʻōnaehana ma muli o ke keakea ʻana o ka papa hana o ka ʻili o ka alveoli, ua ʻōlelo ʻo Huang Bo e loaʻa ka hopena o ia ʻano hoʻohui ʻana ma o ka nasal spray i kekahi hapa.I ka manawa like, hiki i kēia hui ke pāʻani i ka hana o ka hormone anti-inflammatory.He maʻalahi kēia lāʻau lapaʻau, palekana, kūʻai ʻole a maʻalahi hoʻi e hoʻolaha.He hoʻolālā hou ia no ka mālama mua ʻana i ka maʻi COVID-19.